Spatial Proteomics

PIONEERING SPATIAL PROTEOMICS FOR SINGLE CELLS

At Pixelgen we’re taking the most detailed look at cell surface proteins and their spatial relationships to advance our understanding of biology and make possible a new generation of medicines and diagnostics for better health. Watch our founders share their vision for our groundbreaking Molecular Pixelation (MPX) technology.

Pixelgen Technologies Announces Peer-Review Publication on Molecular Pixelation Technology in Nature Methods

Introducing Molecular Pixelation: The Next Dimension in Single Cell Spatial Proteomics - Offering Novel Insights into Human Health

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“My lab is focused on understanding the spatial organization and proteome wiring of human cells. We are now using the Molecular Pixelation Assay (MPX) from Pixelgen to study the spatial dynamics of immune cell surface proteins, with the aim to understand how protein interactions are rewired for functional fine-tuning"
Emma Lundberg
Professor KTH
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This MPX study uncovered new important insights on the effects of the tested compounds, that guided us to differentiate among candidates to move forward in our discovery program
Big International Pharma
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Gaining a better understanding of the diversity of immune landscapes and responses is critical to developing personalized treatments for disease. I'm looking forward to using Pixelgen's Molecular Pixelation technology to investigate the surface proteome of peripheral blood mononuclear cells (PBMCs) to better understand why elderly individuals' responses to COVID vaccinations vary depending on whether or not they have undergone chemotherapy.
Yutaka Suzuki
Professor, University of Tokyo
Ankur Sharma
Our knowledge of the origins of cancer, how tumors grow within their microenvironments and how they respond to therapeutics is rapidly advancing. New technologies such as MPX are critical to building on this knowledge and translating discoveries into therapeutics and diagnostics for disease. The ability to see how proteins interact and the spatial dynamics of the proteome on the surface of single cells could lead to important insights.
Ankur Sharma
Laboratory head at Harry Perkins Institute of Medical Research in Perth, Australia
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"Being able to analyze the spatial distribution and colocalization of proteins in individual white blood cells has tremendous value for our research into how cells are regulated by cell-cell interactions and adapt their function in response to environmental factors”
Petter Brodin
Pediatrician and Professor of pediatric immunology, Imperial College London (UK) & Karolinska Institutet (Stockholm, Sweden)
Jessica Nordlund
From this pilot data, the immediate benefit that I can see with MPX data is not only getting the abundance but also the polarity & colocalization of the cell surface proteins.
Dr. Jessica Nordlund
Associate Professor, Science for Life Laboratory, Uppsala University

Key Features & Benefits



3D Spatial Single Cell Proteomics

Molecular Pixelation (MPX) enables highly resolved cell surface protein maps for deep phenotyping of immune cells. MPX provides a deeper understanding of cell biology, disease-causing mechanisms and drug mode of action.



Unprecedented Spatial Protein Multiplexing

DNA tagged monoclonal antibodies ensure high multiplex analysis of cell surface proteins with validated target specificity. The barcoding approach enables a smooth transition from analog to digital data readout.



In Focus Without a Microscope

Forget your Z-stacks, stitching, auto-fluorescence, fluorophore-bleed through and bleaching! Use a single tube, partitioning-free sample preparation, providing spatially resolved abundance data similar to Confocal and Flow Cytometry, always in focus and from every angle.



Leverage Your Existing NGS Workflow

Obtain powerful single cell protein abundance, polarization and co-localization data with a simple, scalable solution available to any size cell and molecular biology laboratory.

Pixelgen SCSP Kit

Molecular Pixelation for 3D Spatial Analysis of Cell Surface Proteins

The Pixelgen Single Cell Spatial Proteomics Kit, Immunology Panel I, Human (Pixelgen SCSP Kit) is the first high-multiplex and high-thoughput product to convey spatial polarization and co-localization of proteins on the cell surface in 3D, offering new insights into the biology in health and disease.

About Pixelgen Technologies

Our revolutionary Molecular Pixelation technology brings a new spatial dimension to the analysis of cell-surface proteins, enabling the advancement of basic science and the acceleration of new therapeutics.

Pixelgen Technologies

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