CELL SURFACE PROTEIN INTERACTOMICS
TECHNOLOGY
The dynamic cell surface protein interactome is essential to understanding the molecular mechanisms of cell function. This aspect of cell biology is largely unexplored due to the lack of high-throughput, high-multiplex spatial proteomics technologies.
Discover the molecular basis of cell function through protein interactomics by Proximity Networks
Proteins work together on the cell surface by clustering or forming multi-protein domains to control cell function. The groundbreaking Proximity Network Assay enables high-throughput mapping of the dynamic protein interactome of the cell surface of single cells. With nanoscale resolution averaging 50nm, individual proteins are connected together to form a spatial network of the location of cell surface targets. Protein colocalization, clustering, and abundance are reported on a single cell level providing the understanding of proteomic differences in heterogeneous cell populations.