Spatial cell biology - Technology

Molecular Pixelation - Proteomics in 3D for Single Cells

Cellular systems are functionally defined by the amount of, and spatial location of proteins, forming an elaborate and highly orchestrated network. Molecular Pixelation offers deep cellular phenotyping by revealing spatial protein correlation and colocalization at high multiplex.

Spatial cell biology


Toward a Better Understanding of Dynamic Cell Regulation. While significant cell mapping efforts have focused on the gene expression characteristics of single cells, understanding dynamic cell regulation through spatial reorganization of proteins remains largely uncharted.

Molecular Pixelation Offers Detailed Three-Dimensional Spatial Mapping of Cell Surface Proteins

Our revolutionary Molecular Pixelation technology delivers next dimension, single-cell, spatial proteomics to advance human health from basic research to drug discovery and development and diagnostics. Molecular Pixelation offers deep cellular phenotyping by revealing polarization and co-localization of proteins at high multiplex. Pixelation is enabled by cell-surface zonation using DNA barcoding, and data is then presented in a three-dimensional spatial map.

Key Features & Benefits

3D Spatial Single Cell Proteomics

Molecular Pixelation (MPX) enables highly resolved cell surface protein maps for deep phenotyping of immune cells. MPX provides a deeper understanding of cell biology, disease causing mechanisms and drug mode of action.

Unprecedented spatial protein multiplexing

DNA tagged monoclonal antibodies ensure high multiplex analysis of cell surface proteins with validated target specificity. The barcoding approach enables a smooth transition from analog to digital data readout.

In Focus without a Microscope

Forget your Z-stacks, stitching, auto-fluorescence, fluorophore-bleed through and bleaching! Use a single tube, partitioning-free sample preparation, providing spatially resolved abundance data similar to Confocal and Flow Cytometry, always in focus and from every angle.

Leverage your existing NGS workflow

Obtain powerful single cell protein abundance, polarization and co-localization data with a simple, scalable solution available to any size cell and molecular biology laboratory.

Pixelgen Technologies

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