Cell surface proteins

Why Proteins?

The cell surface proteome is the dynamic and spatial location of proteins that change with the state and activity of the cell, which in turn determines the cell’s activity in health and disease.

Cell surface proteins


Protein spatial architecture enables cell-cell communication, mobility, structure, and immunological activities such as the immune synapse.

These fundamental aspects of cell biology are poorly understood due to current technologies’ limitations to facilitate larger studies and data driven science at a scale, resolution and throughput needed to shred the necessary light over the lateral movement of cell surface proteins. To address this need, Pixelgen Technologies has developed the Molecular Pixelation workflow for immune single cells which generates spatial cell surface protein location data.

This information is crucial for the understanding of the different stages of human health and disease as well as the mode-of-action of drugs.

Protein spatial architecture

How single cells are organized on the surface of the proteome and how they interact can determine health and disease. Protein spatial architecture, for example, enables communication between cells, movement, structure and immunological activity. Unfortunately, existing tools such as microscopy are limiting large-scale, data-driven science because they are unable to see at a high enough resolution and process at adequate throughput.

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