Protein cells

Protein list

Cell surface proteins are proteins embedded in or spanning the layer of cell membranes. These proteins are integral to the way in which a cell interacts with the environment around it, including other cells.

 

Each Molecular Pixelation assays has been thoroughly evaluated and optimized to fit into a broad immunological multiplex panel.

Protein selection

The proteins that make up the structure of the panel have been selected based on feedback from thought leaders as well as in-depth literature evaluation.

One important part of the panel consists of the backbone proteins to distinguish between different immunological cell types.

A broad spectrum of proteins were also included with different abundance on the cell surface have been chosen. The highly abundant proteins serve as a connectivity baseline in order to ensure capturing also proteins with lower expression.

Well-known protein markers as well as more exploratory proteins have been included.

In addition, subsets of scientifically interesting targets not yet fully understood have also been included in the panel.

The majority of the panel is composed of markers expressed on:

  • T lymphocytes
  • B lymphocytes
  • Monocytes
  • Macrophages
  • NK cells
Beta-2-microglobulin Antigen-presenting glycoprotein CD1d
T-cell surface antigen CD2 T-cell surface glycoprotein CD3 epsilon chain
T-cell surface glycoprotein CD4 T-cell surface glycoprotein CD5
T-cell surface glycoprotein CD5 T-cell surface glycoprotein CD8 alpha chain/ beta chain
CD9 antigen Integrin alpha-L
Integrin alpha-M Integrin alpha-X
Monocyte differentiation antigen CD14 Low affinity immunoglobulin gamma Fc region receptor III-A or -B
Integrin beta 2 B-lymphocyte antigen CD19
B-lymphocyte antigen CD20 B-cell receptor CD22
Interleukin-2 receptor subunit alpha Dipeptidyl peptidase 4
CD27 antigen Integrin beta-1
Low affinity immunoglobulin gamma Fc region receptor II-b Myeloid cell surface antigen CD33
Complement receptor type 1 Platelet glycoprotein 4
Leukocyte antigen CD37 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Tumor necrosis factor receptor superfamily member 5 Integrin alpha-IIb
Leukosialin CD44 antigen
Receptor-type tyrosine-protein phosphatase C. All 6 isoforms (ABC, AB, BC, B and O) Receptor-type tyrosine-protein phosphatase C. All 6 isoforms (ABC, AB and A)
Receptor-type tyrosine-protein phosphatase C. All 6 isoforms (ABC, AB, BC and B) Leukocyte surface antigen CD47
CD48 antigen Integrin alpha-4
Intercellular adhesion molecule 3 CAMPATH-1 antigen
Leukocyte surface antigen CD53 Intercellular adhesion molecule 1
Complement decay-accelerating factor CD59 glycoprotein
P-selectin High affinity immunoglobulin gamma Fc receptor I
Early activation antigen CD69 Transferrin receptor protein 1
B-cell differentiation antigen CD72 CD82 antigen
SLAM family member 5 T-lymphocyte activation antigen CD86
Intercellular adhesion molecule 2 Interleukin-7 receptor subunit alpha
Tumor necrosis factor receptor superfamily member 9 Signaling lymphocytic activation molecule
Cytotoxic T-lymphocyte protein 4 CD40 ligand
Killer cell immunoglobulin-like receptor 2D Killer cell lectin-like receptor subfamily B member 1
P-selectin glycoprotein ligand 1 Scavenger receptor cysteine-rich type 1 protein M130
C-C chemokine receptor type 7 OX-2 membrane glycoprotein
T-lymphocyte surface antigen Ly-9 Natural killer cell receptor 2B4
Tumor necrosis factor receptor superfamily member 13C (BAFFR) Programmed cell death 1 ligand 1
Inducible T-cell costimulator Programmed cell death protein 1
NKG2-D type II integral membrane protein Natural cytotoxicity triggering receptor 3
Sialic acid-binding Ig-like lectin 7 (SIGLEC-7) T-cell antigen receptor b (TCRB)
HLA class I histocompatibility antigen, A, B and C alpha chain HLA class II histocompatibility antigen, DR
B-actin MG1-45 immunoglobulin; Mouse IgG1, kappa Isotype Control

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